Epilepsy Research Today is a free monthly online journal that collates and summarizes the latest research about Epilepsy, including details on symptoms, causes, treatment, drugs, information.

Combined EEG-fMRI and tractography to visualise propagation of epileptic activity.

Hamandi K, Powell HW, Laufs H, Symms MR, Barker GJ, Parker GJ, Lemieux L, Duncan JS

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK. hamandik@cardiff.ac.uk

In a patient with refractory temporal lobe epilepsy, EEG-fMRI showed activation in association with left anterior temporal interictal discharges, in the left temporal, parietal and occipital lobes. Dynamic causal modelling suggested propagation of neural activity from the temporal focus to the area of occipital activation. Tractography showed connections from the site of temporal lobe activation to the site of occipital activation. This demonstrates the principle of combining EEG-fMRI and tractography to delineate the pathways of propagation of epileptic activity.

Published 14 April 2008 in J Neurol Neurosurg Psychiatry, 79(5): 594-7.
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