Epilepsy Research Today is a free monthly online journal that collates and summarizes the latest research about Epilepsy, including details on symptoms, causes, treatment, drugs, information.

Predictors of outcome after temporal lobectomy for the treatment of intractable epilepsy.

Jeha LE, Najm IM, Bingaman WE, Khandwala F, Widdess-Walsh P, Morris HH, Dinner DS, Nair D, Foldvary-Schaeffer N, Prayson RA, Comair Y, O'Brien R, Bulacio J, Gupta A, Lüders HO

Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. jehil@ccf.org

To assess short- and long-term seizure freedom, the authors reviewed 371 patients who underwent anterior temporal lobectomy to treat pharmacoresistant epilepsy. The mean follow-up duration was 5.5 years (range 1 to 14.1 years). Fifty-three percent of patients were seizure free at 10 years. The authors identified multiple predictors of recurrence. Results of EEG performed 6 months postoperatively correlated with occurrence and severity of seizure recurrence, in addition to breakthrough seizures with discontinuation of antiepileptic drugs.

Published 27 June 2006 in Neurology, 66(12): 1938-40.
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