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A patient using ziprasidone with polydipsia, seizure, hyponatremia and rhabdomyolysis.

Akkaya C, Sarandol A, Sivrioglu EY, Kotan Z, Kirli S

Department of Psychiatry, Uludag University Faculty of Medicine, Bursa, Turkey. cakkaya@uludag.edu.tr

We aimed to report a case with rhabdomyolysis related to hyponatremia and/or its correction. A 32-year-old male schizophrenic patient on ziprasidone treatment was admitted to the hospital following a seizure. Patient had primary polydipsia and secondarily developed hyponatremia. After the correction of hyponatremia, due to the high liver enzyme levels, he was diagnosed as rhabdomyolysis. Although the role of antipsychotics in this situation is speculative, development of rhabdomyolysis related to hyponatremia and/or its correction should not be underestimated and should be assessed thoroughly.

Published 30 October 2006 in Prog Neuropsychopharmacol Biol Psychiatry, 30(8): 1535-8.
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